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Matters came to a head on 23 August 1572 with the St Bartholomew's Day Massacre, when Catholic mobs killed an estimated 3,000 Protestants on the instructions of King Charles VIII. His successor, King Henry III, attempted to find a peaceful solution but the city's population turned against him and forced him to flee in May 1588. The following year, he was assassinated by a fanatical Dominican monk, bringing the Valois line to a premature end.

During the 11th century the city spread to the Right Bank. In the 12th and 13th centuries, which included the reign of Philip II Augustus (1180-1223), the city grew strongly. Main thoroughfares were paved, the first Louvre was built as a fortress, and several churches, including the Cathedral of Notre-Dame, were constructed or begun.

The city emerged into an energetic but restless interwar period, enlivened by the arrival of glamorous émigrés such as Josephine Baker. It was a troubled political period, however, especially when the Great Depression hit Paris.

Paris' history in the 14th century was thus punctuated by outbreaks of plague, political violence and popular uprisings. In January 1357, Étienne Marcel, the Provost of Paris, led a merchants' revolt in a bid to curb the power of the monarchy and obtain privileges for the city and the Estates General, which had met for the first time in Paris in 1347. After initial concessions by the Crown, the city was retaken by royalist forces in 1358 and Marcel and his followers were killed.

The new rulers organised themselves into a five-man Directoire but had only a shaky grip on power. In 1795 they were saved from a royalist revolt by a young army officer named Napoleon Bonaparte, who dispersed a hostile Parisian mob by the simple expedient of firing into it with cannons at point-blank range.

Locally, inhabitants of the Paris suburbs are known as banlieusards. Inhabitants of the whole Paris metropolitan area are known as Franciliens, i.e. from Île-de-France.

The Capetian line died out in 1328, leaving no male heir. Edward II of England claimed the French throne by virtue of his descent (via his mother) from Philip IV of France. This was rejected by the French barons, who supported the rival claim of Philippe of Valois (Philip VI of France). The Hundred Years' War thus began, followed swiftly by the arrival of the Black Death.

Paris was occupied by a Gallic tribe until the Romans arrived in 52 BC. The invaders referred to the previous occupants as the Parisii, but called their new city Lutetia, meaning "marshy place". About fifty years later the city had spread to the left bank of the Seine, now known as the Latin Quarter, and had been renamed "Paris".

Napoleon's brief return from exile in 1815 saw him pass through Paris, en route to destiny at Waterloo on 18 June. His replacements, the restored Bourbon monarchs Louis XVIII (1814, 1815-1824) and Charles X (1824-1830), managed between them to provoke yet another revolution in Paris, confirming the saying that the Bourbons could "learn nothing and forget nothing."